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Science 9 August 2002:
Vol. 297. no. 5583, pp. 945 - 947
DOI: 10.1126/science.1075472
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Perspectives

GENOMICS:
Gene Duplication and Evolution

Michael Lynch

The duplication of short chromosomal segments in the genome may contribute to the formation of new species. In his Perspective, Lynch explores the potential implications of new work (Bailey et al.) that calculates the number of segmental duplications in the human genome, as well as other recent comparative data on fine-scale changes in chromosomal architecture.

The author is in the Department of Biology, Indiana University, Bloomington, IN 47405, USA. E-mail: mlynch{at}bio.indiana.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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M. W. Robinson, J. F. Tort, J. Lowther, S. M. Donnelly, E. Wong, W. Xu, C. M. Stack, M. Padula, B. Herbert, and J. P. Dalton (2008)
Mol. Cell. Proteomics 7, 1111-1123
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Evolutionary Origins of a Novel Host Plant Detoxification Gene in Butterflies.
H. M. Fischer, C. W. Wheat, D. G. Heckel, and H. Vogel (2008)
Mol. Biol. Evol. 25, 809-820
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Partitioned expression of duplicated genes during development and evolution of a single cell in a polyploid plant.
R. Hovav, J. A. Udall, B. Chaudhary, R. Rapp, L. Flagel, and J. F. Wendel (2008)
PNAS 105, 6191-6195
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Quantitative Assay of Deletion or Duplication Genotype by Capillary Electrophoresis System: Application in Prader-Willi Syndrome and Duchenne Muscular Dystrophy.
C.-C. Hung, C.-P. Chen, S.-P. Lin, S.-C. Chien, C.-N. Lee, W.-F. Cheng, W.-S. Hsieh, M. S. Liu, Y.-N. Su, and W.-L. Lin (2006)
Clin. Chem. 52, 2203-2210
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Morphological and molecular phylogenetic context of the angiosperms: contrasting the 'top-down' and 'bottom-up' approaches used to infer the likely characteristics of the first flowers.
R. M. Bateman, J. Hilton, and P. J. Rudall (2006)
J. Exp. Bot. 57, 3471-3503
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Evolution of the Cichlid Visual Palette through Ontogenetic Subfunctionalization of the Opsin Gene Arrays.
T. C. Spady, J. W. L. Parry, P. R. Robinson, D. M. Hunt, J. K. Bowmaker, and K. L. Carleton (2006)
Mol. Biol. Evol. 23, 1538-1547
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The evolutionary dynamics of {alpha}-satellite.
M. K. Rudd, G. A. Wray, and H. F. Willard (2006)
Genome Res. 16, 88-96
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Gene and Genome Duplication in Acanthamoeba polyphaga Mimivirus.
K. Suhre (2005)
J. Virol. 79, 14095-14101
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Duplication processes in Saccharomyces cerevisiae haploid strains.
J. Schacherer, J. de Montigny, A. Welcker, J.-L. Souciet, and S. Potier (2005)
Nucleic Acids Res. 33, 6319-6326
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Detection, Characterization, and In Vitro and In Vivo Expression of Genes Encoding S-Proteins in Lactobacillus gallinarum Strains Isolated from Chicken Crops.
K. E. Hagen, L. L. Guan, G. W. Tannock, D. R. Korver, and G. E. Allison (2005)
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The Coevolution of Insect Muscle TpnT and TpnI Gene Isoforms.
R. Herranz, J. Mateos, J. A. Mas, E. Garcia-Zaragoza, M. Cervera, and R. Marco (2005)
Mol. Biol. Evol. 22, 2231-2242
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A parallel graph decomposition algorithm for DNA sequencing with nanopores.
S. H. Bokhari and J. R. Sauer (2005)
Bioinformatics 21, 889-896
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Segmental trisomy of chromosome 17: A mouse model of human aneuploidy syndromes.
T. Vacik, M. Ort, S. Gregorova, P. Strnad, R. Blatny, N. Conte, A. Bradley, J. Bures, and J. Forejt (2005)
PNAS 102, 4500-4505
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Organ-Specific Silencing of Duplicated Genes in a Newly Synthesized Cotton Allotetraploid.
K. L. Adams, R. Percifield, and J. F. Wendel (2004)
Genetics 168, 2217-2226
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Reconstructing patterns of reticulate evolution in plants.
C. R. Linder and L. H. Rieseberg (2004)
Am. J. Botany 91, 1700-1708
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Recovery of a Function Involving Gene Duplication by Retroposition in Saccharomyces cerevisiae.
J. Schacherer, Y. Tourrette, J.-L. Souciet, S. Potier, and J. de Montigny (2004)
Genome Res. 14, 1291-1297
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Widespread Paleopolyploidy in Model Plant Species Inferred from Age Distributions of Duplicate Genes.
G. Blanc and K. H. Wolfe (2004)
PLANT CELL 16, 1667-1678
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A Sensitive Method for Detecting Variation in Copy Numbers of Duplicated Genes.
G. Pielberg, A. E. Day, G. S. Plastow, and L. Andersson (2003)
Genome Res. 13, 2171-2177
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New Evidence for Genome-Wide Duplications at the Origin of Vertebrates Using an Amphioxus Gene Set and Completed Animal Genomes.
G. Panopoulou, S. Hennig, D. Groth, A. Krause, A. J. Poustka, R. Herwig, M. Vingron, and H. Lehrach (2003)
Genome Res. 13, 1056-1066
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Science. ISSN 0036-8075 (print), 1095-9203 (online)