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DNA viruses must first replicate their genome in the nucleus of the host cell before forming subviral particles that cross into the cytoplasm for the final stages of virion maturation. However, the nuclear envelope provides a physical barrier to the movement of subviral particles into the cytoplasm. In their Perspective, Sanchez and Spector discuss new work (Muranyi et al.) that reveals how cytomegalovirus recruits a host cell protein kinase C to modify the nuclear lamin meshwork of the nuclear envelope, thus enabling subviral particles to exit the nucleus.
The authors are in the Molecular Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA. E-mail: dspector{at}ucsd.edu
BFRF1 of Epstein-Barr Virus Is Essential for Efficient Primary Viral Envelopment and Egress.
A. Farina, R. Feederle, S. Raffa, R. Gonnella, R. Santarelli, L. Frati, A. Angeloni, M. R. Torrisi, A. Faggioni, and H.-J. Delecluse (2005)
J. Virol.
79, 3703-3712
|Abstract »|Full Text »|PDF »
Entry of Pseudorabies Virus: an Immunogold-Labeling Study.
H. Granzow, B. G. Klupp, and T. C. Mettenleiter (2005)
J. Virol.
79, 3200-3205
|Abstract »|Full Text »|PDF »
Global Analysis of Host Cell Gene Expression Late during Cytomegalovirus Infection Reveals Extensive Dysregulation of Cell Cycle Gene Expression and Induction of Pseudomitosis Independent of US28 Function.
