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Science 26 July 2002:
Vol. 297. no. 5581, pp. 529 - 531
DOI: 10.1126/science.1075453
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Perspectives

CELL BIOLOGY:
A Last GASP for GPCRs?

John A. Gray and Bryan L. Roth

Once activated by their ligands, many G-protein-coupled receptors (GPCRs) are internalized into endocytic compartments within the cell. Here, they are sorted to either a recycling or a degradative pathway. In their Perspective, Gray and Roth discuss new work (Whistler et al.) that identifies a protein called GASP that is important for the lysosomal targeting of certain GPCRs.

The authors are in the Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH 44106-4936, USA. E-mail: roth{at}biocserver.bioc.cwru.edu

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The Interaction of a Constitutively Active Arrestin with the Arrestin-Insensitive 5-HT2A Receptor Induces Agonist-Independent Internalization.
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