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Science 19 July 2002:
Vol. 297. no. 5580, pp. 343 - 344
DOI: 10.1126/science.1073126

Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

PARASITOLOGY:
Enhanced: Drugs to Combat Tropical Protozoan Parasites

Michael H. Gelb and Wim G. J. Hol

Tropical protozoan parasites are the scourge of the developing world, causing devastating diseases, such as malaria, Chagas' disease, and leishmaniasis. These diseases not only are a huge cause of human misery but also are holding back the economic progress of many developing countries. A pair of Perspectives--by Hol and Gelb, and by Long and Hoffman--report the proceedings of two recent Keystone meetings that examined progress in developing new drugs and vaccines to combat these terrible diseases.


M. H. Gelb and W. Hol are in the Departments of Chemistry and Biochemistry, respectively, University of Washington, Seattle, WA 98195, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
2,N6-Disubstituted Adenosine Analogs with Antitrypanosomal and Antimalarial Activities.
B. Rodenko, A. M. van der Burg, M. J. Wanner, M. Kaiser, R. Brun, M. Gould, H. P. de Koning, and G.-J. Koomen (2007)
Antimicrob. Agents Chemother. 51, 3796-3802
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Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein.
A. V. Lobanov, S. Gromer, G. Salinas, and V. N. Gladyshev (2006)
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Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase.
A. C. Nyborg, T. B. Ladd, K. Jansen, T. Kukar, and T. E. Golde (2006)
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Secondary loss of chloroplasts in trypanosomes.
W. Martin and P. Borst (2003)
PNAS 100, 765-767
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