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Science 12 July 2002:
Vol. 297. no. 5579, pp. 200 - 201
DOI: 10.1126/science.1074592
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Perspectives

CELL BIOLOGY:
PARP-1--a Perpetrator of Apoptotic Cell Death?

Alberto Chiarugi and Michael A. Moskowitz

The caspase-dependent pathway of programmed cell death has been well documented. In their Perspective, Chiarugi and Moskowitz report on new findings (Yu et al.) that reveal a caspase-independent pathway of apoptosis driven by the nuclear enzyme PARP-1.

A. Chiarugi is in the Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy, and the Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. E-mail: alberto.chiarugi{at}umassmed.edu M. A. Moskowitz is at the Neuroscience Center, Departments of Radiology, Neurology, and Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. E-mail: moskowitz{at}helix.mgh.harvard.edu

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E-Letters:

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PARP-1 and AIF produce cellular necrosis, not apoptosis
Denson G. Fujikawa
Science Online, 29 Jul 2002 [Full text]

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