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It might be assumed that mechanisms for the biosynthesis of essential DNA precursors would be conserved in all organisms. However, Murzin discusses new work (Myllykallio et al.) showing that a large family of enzymes, named ThyX, synthesize thymidylate by an alternate mechanism. The structure of ThyX has been determined independently and together these findings pave the way for rational drug design.
The author is in the MRC Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, UK. E-mail: agm{at}mrc-lmb.cam.ac.uk
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In Science Magazine
REPORTS
Hannu Myllykallio, Gerard Lipowski, Damien Leduc, Jonathan Filee, Patrick Forterre, and Ursula Liebl (5 July 2002) Science297 (5578), 105.
[DOI: 10.1126/science.1072113] |Abstract »|Full Text »|PDF »|Supplemental Data »
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