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Science 28 June 2002:
Vol. 296. no. 5577, pp. 2347 - 2348
DOI: 10.1126/science.1073589
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Perspectives

MOLECULAR DYNAMICS:
Biomolecules See the Light

David W. Pratt

Detailed knowledge of the dynamics of biomolecules is crucial for the treatment of human diseases, but is often hard to come by. In his Perspective, Pratt highlights the report of Dian et al., who have developed a method for manipulating the populations of different conformational states of small biomolecules that allows distinct folding pathways to be distinguished. If the method can be extended to larger molecules, it should provide important insights into their dynamics.

The author is at the Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. E-mail: pratt{at}pitt.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Vibrational Transition Moment Angles in Isolated Biomolecules: A Structural Tool.
F. Dong and R. E. Miller (2002)
Science 298, 1227-1230
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