Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 June 2002:
Vol. 296. no. 5577, pp. 2325 - 2326
DOI: 10.1126/science.296.5577.2325
Prev | Table of Contents | Next

News Focus

VACCINES:
Monkey Puzzles

Jon Cohen

Almost 2 decades after HIV was identified as the cause of AIDS, researchers are still debating which immune responses are likely to provide the best protection against the virus. The answer is proving elusive in part because experiments with monkeys are coming up with puzzling, even contradictory, data. As a growing number of vaccines move through the pipeline toward clinical trials, these experiments are raising serious questions about most of the vaccine approaches now being pursued.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Simian Immunodeficiency Virus Promoter Exchange Results in a Highly Attenuated Strain That Protects against Uncloned Challenge Virus.
P. Blancou, N. Chenciner, R. H. T. Fang, V. Monceaux, M.-C. Cumont, D. Guetard, B. Hurtrel, and S. Wain-Hobson (2004)
J. Virol. 78, 1080-1092
   Abstract »    Full Text »    PDF »
Potent, Persistent Induction and Modulation of Cellular Immune Responses in Rhesus Macaques Primed with Ad5hr-Simian Immunodeficiency Virus (SIV) env/rev, gag, and/or nef Vaccines and Boosted with SIV gp120.
L. J. Patterson, N. Malkevitch, J. Pinczewski, D. Venzon, Y. Lou, B. Peng, C. Munch, M. Leonard, E. Richardson, K. Aldrich, et al. (2003)
J. Virol. 77, 8607-8620
   Abstract »    Full Text »    PDF »
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.
L. Reynolds, C. Ullman, M. Moore, M. Isalan, M. J. West, P. Clapham, A. Klug, and Y. Choo (2003)
PNAS 100, 1615-1620
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)