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Science 28 June 2002:
Vol. 296. no. 5577, pp. 2320 - 2324
DOI: 10.1126/science.296.5577.2320

News Focus

THERAPIES:
Confronting the Limits of Success

Jon Cohen

Six years ago, new cocktails of anti-HIV drugs transformed prospects for infected people in industrialized countries. Now, serious limitations have become apparent, including numerous long-term drug side effects and a rise in transmission of drug-resistant strains of HIV. As researchers prepare to gather in Barcelona, Spain, next week for the XIV International AIDS Conference, this special package looks at two pressing issues on the agenda: problems limiting the effectiveness of current treatments and puzzles over what kinds of immune responses might lead to vaccines.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of Human Immunodeficiency Virus Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection..
M. Guadalupe, S. Sankaran, M. D. George, E. Reay, D. Verhoeven, B. L. Shacklett, J. Flamm, J. Wegelin, T. Prindiville, and S. Dandekar (2006)
J. Virol. 80, 8236-8247
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Antiretroviral Drugs for Tuberculosis Control in the Era of HIV/AIDS.
B. G. Williams and C. Dye (2003)
Science 301, 1535-1537
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Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.
L. Reynolds, C. Ullman, M. Moore, M. Isalan, M. J. West, P. Clapham, A. Klug, and Y. Choo (2003)
PNAS 100, 1615-1620
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Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy.
W. Lewis (2003)
Am J Physiol Heart Circ Physiol 284, H1-H9
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