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NEURODEGENERATION: A Glutamine-Rich Trail Leads to Transcription Factors
Richard N. Freiman and Robert Tjian
The tragic neurodegenerative disease Huntington's strikes in midlife and is ultimately fatal. Encouraging new results (Dunah et al.), eloquently explained in a Perspective by Freiman and Tjian, reveal that a glutamine expansion in the mutant huntingtin protein disrupts transcriptional activation by Sp1 and TAFII130, leading to loss of expression of genes essential for neuronal survival.
The authors are in the Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. E-mail: jmlim{at}uclink4.berkeley.edu
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REPORTS
Anthone W. Dunah, Hyunkyung Jeong, April Griffin, Yong-Man Kim, David G. Standaert, Steven M. Hersch, M. Maral Mouradian, Anne B. Young, Naoko Tanese, and Dimitri Krainc (21 June 2002) Science296 (5576), 2238.
[DOI: 10.1126/science.1072613] |Abstract »|Full Text »|PDF »|Supplemental Data »
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