Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 21 June 2002:
Vol. 296. no. 5576, pp. 2126 - 2129
DOI: 10.1126/science.296.5576.2126
Prev | Table of Contents | Next

News Focus

STEM CELLS:
Plasticity: Time for a Reappraisal?

Constance Holden and Gretchen Vogel

Long-standing biological dogma--that a cell, once committed, can't alter its fate--has been challenged by recent research. But now scientists are taking a more critical look and finding that some apparent reprogramming of adult cells might instead be a case of cell fusion, prompting calls to establish rigorous standards for demonstrating plasticity. The political stakes are high, because opponents of embryonic stem cell research are using the prospect of reprogramming of adult cells to argue that embryonic stem cells are not needed to develop medical treatments.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
What happened to the stem cells?.
T Hviid Nielsen (2008)
J. Med. Ethics 34, 852-857
   Abstract »    Full Text »    PDF »
Using "Mighty Mouse" to understand masticatory plasticity: myostatin-deficient mice and musculoskeletal function.
M. J. Ravosa, E. K. Lopez, R. A. Menegaz, S. R. Stock, M. S. Stack, and M. W. Hamrick (2008)
Integr. Comp. Biol. 48, 345-359
   Abstract »    Full Text »    PDF »
Tissue Engineering for Cardiac Valve Surgery.
J. E. Mayer (2008)
Card. Surg. Adult 3, 1649-1656
   Full Text »
Pushing the limit: masticatory stress and adaptive plasticity in mammalian craniomandibular joints.
M. J. Ravosa, R. Kunwar, S. R. Stock, and M. S. Stack (2007)
J. Exp. Biol. 210, 628-641
   Abstract »    Full Text »    PDF »
Formation of Pancreatic Duct Epithelium from Bone Marrow During Neonatal Development.
X. Wang, S. Ge, I. Gonzalez, G. McNamara, C. B. Rountree, K. K. Xi, G. Huang, A. Bhushan, and G. M. Crooks (2006)
Stem Cells 24, 307-314
   Abstract »    Full Text »    PDF »
Identification of Novel Resident Pulmonary Stem Cells: Form and Function of the Lung Side Population.
S. M. Majka, M. A. Beutz, M. Hagen, A. A. Izzo, N. Voelkel, and K. M. Helm (2005)
Stem Cells 23, 1073-1081
   Abstract »    Full Text »    PDF »
Donor Marker Infidelity in Transgenic Hematopoietic Stem Cells.
D. A. Anderson, Y. Wu, S. Jiang, X. Zhang, P. R. Streeter, G. J. Spangrude, D. R. Archer, and W. H. Fleming (2005)
Stem Cells 23, 638-643
   Abstract »    Full Text »    PDF »
Epithelial Tissue Chimerism after Human Hematopoietic Cell Transplantation Is a Real Phenomenon.
A. Spyridonidis, A. Schmitt-Graff, T. Tomann, A. Dwenger, M. Follo, D. Behringer, and J. Finke (2004)
Am. J. Pathol. 164, 1147-1155
   Abstract »    Full Text »    PDF »
Recipes for adult stem cell plasticity: fusion cuisine or readymade?.
M R Alison, R Poulsom, W R Otto, P Vig, M Brittan, N C Direkze, M Lovell, T C Fang, S L Preston, and N A Wright (2004)
J. Clin. Pathol. 57, 113-120
   Abstract »    Full Text »    PDF »
Stem Cells: Review and Update.
K. G. Sylvester and M. T. Longaker (2004)
Arch Surg 139, 93-99
   Abstract »    Full Text »    PDF »
Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model.
F. Norol, P. Merlet, R. Isnard, P. Sebillon, N. Bonnet, C. Cailliot, C. Carrion, M. Ribeiro, F. Charlotte, P. Pradeau, et al. (2003)
Blood 102, 4361-4368
   Abstract »    Full Text »    PDF »
Microsurgical and laser ablation analysis of interactions between the zones and layers of the tomato shoot apical meristem.
D. Reinhardt, M. Frenz, T. Mandel, and C. Kuhlemeier (2003)
Development 130, 4073-4083
   Abstract »    Full Text »    PDF »
Expression of Functional CXCR4 by Muscle Satellite Cells and Secretion of SDF-1 by Muscle-Derived Fibroblasts is Associated with the Presence of Both Muscle Progenitors in Bone Marrow and Hematopoietic Stem/Progenitor Cells in Muscles.
M. Z. Ratajczak, M. Majka, M. Kucia, J. Drukala, Z. Pietrzkowski, S. Peiper, and A. Janowska-Wieczorek (2003)
Stem Cells 21, 363-371
   Abstract »    Full Text »    PDF »
Origin of Smooth Muscle Progenitor Cells: Different Conclusions From Different Models * Response.
M. Sata, K. Tanaka, R. Nagai, Y. Hu, H. Dietrich, F. Davison, M. Mayr, Q. Xu, B. Ludewig, M. Erdel, et al. (2003)
Circulation 107 , e106-e107
   Full Text »    PDF »
The new stem cell biology: something for everyone.
S L Preston, M R Alison, S J Forbes, N C Direkze, R Poulsom, and N A Wright (2003)
Mol. Pathol. 56, 86-96
   Abstract »    Full Text »    PDF »
Plastic adult stem cells: will they graduate from the school of hard knocks?.
M. R. Alison, R. Poulsom, W. R. Otto, P. Vig, M. Brittan, N. C. Direkze, S. L. Preston, and N. A. Wright (2003)
J. Cell Sci. 116, 599-603
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)