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COLD SPRING HARBOR, NEW YORK--As researchers begin comparing newly sequenced genomes, numerous surprises are emerging, as described at a genome meeting held here from 7 to 11 May. For one, some of the noncoding DNA that was believed to be useless turns out to be highly conserved among humans and mice--an indication that it might have an important function after all. Another unexpected finding is that the rates at which different DNA sequences within the same genome change through time vary significantly. As a result of these discoveries, biologists are rethinking their views of how genomes operate--and shedding some of their "gene-centric" views in the process.
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In Science Magazine
PERSPECTIVES
Neal G. Copeland, Nancy A. Jenkins, and Stephen J. O'Brien (31 May 2002) Science296 (5573), 1617.
[DOI: 10.1126/science.1073127] |Summary »|Full Text »|PDF »
RESEARCH ARTICLES
Richard J. Mural, Mark D. Adams, Eugene W. Myers, Hamilton O. Smith, George L. Gabor Miklos, Ron Wides, Aaron Halpern, Peter W. Li, Granger G. Sutton, Joe Nadeau, Steven L. Salzberg, Robert A. Holt, Chinnappa D. Kodira, Fu Lu, Lin Chen, Zuoming Deng, Carlos C. Evangelista, Weiniu Gan, Thomas J. Heiman, Jiayin Li, Zhenya Li, Gennady V. Merkulov, Natalia V. Milshina, Ashwinikumar K. Naik, Rong Qi, Bixiong Chris Shue, Aihui Wang, Jian Wang, Xin Wang, Xianghe Yan, Jane Ye, Shibu Yooseph, Qi Zhao, Liansheng Zheng, Shiaoping C. Zhu, Kendra Biddick, Randall Bolanos, Arthur L. Delcher, Ian M. Dew, Daniel Fasulo, Michael J. Flanigan, Daniel H. Huson, Saul A. Kravitz, Jason R. Miller, Clark M. Mobarry, Knut Reinert, Karin A. Remington, Qing Zhang, Xiangqun H. Zheng, Deborah R. Nusskern, Zhongwu Lai, Yiding Lei, Wenyan Zhong, Alison Yao, Ping Guan, Rui-Ru Ji, Zhiping Gu, Zhen-Yuan Wang, Fei Zhong, Chunlin Xiao, Chia-Chien Chiang, Mark Yandell, Jennifer R. Wortman, Peter G. Amanatides, Suzanne L. Hladun, Eric C. Pratts, Jeffery E. Johnson, Kristina L. Dodson, Kerry J. Woodford, Cheryl A. Evans, Barry Gropman, Douglas B. Rusch, Eli Venter, Mei Wang, Thomas J. Smith, Jarrett T. Houck, Donald E. Tompkins, Charles Haynes, Debbie Jacob, Soo H. Chin, David R. Allen, Carl E. Dahlke, Robert Sanders, Kelvin Li, Xiangjun Liu, Alexander A. Levitsky, William H. Majoros, Quan Chen, Ashley C. Xia, John R. Lopez, Michael T. Donnelly, Matthew H. Newman, Anna Glodek, Cheryl L. Kraft, Marc Nodell, Feroze Ali, Hui-Jin An, Danita Baldwin-Pitts, Karen Y. Beeson, Shuang Cai, Mark Carnes, Amy Carver, Parris M. Caulk, Angela Center, Yen-Hui Chen, Ming-Lai Cheng, My D. Coyne, Michelle Crowder, Steven Danaher, Lionel B. Davenport, Raymond Desilets, Susanne M. Dietz, Lisa Doup, Patrick Dullaghan, Steven Ferriera, Carl R. Fosler, Harold C. Gire, Andres Gluecksmann, Jeannine D. Gocayne, Jonathan Gray, Brit Hart, Jason Haynes, Jeffery Hoover, Tim Howland, Chinyere Ibegwam, Mena Jalali, David Johns, Leslie Kline, Daniel S. Ma, Steven MacCawley, Anand Magoon, Felecia Mann, David May, Tina C. McIntosh, Somil Mehta, Linda Moy, Mee C. Moy, Brian J. Murphy, Sean D. Murphy, Keith A. Nelson, Zubeda Nuri, Kimberly A. Parker, Alexandre C. Prudhomme, Vinita N. Puri, Hina Qureshi, John C. Raley, Matthew S. Reardon, Megan A. Regier, Yu-Hui C. Rogers, Deanna L. Romblad, Jakob Schutz, John L. Scott, Richard Scott, Cynthia D. Sitter, Michella Smallwood, Arlan C. Sprague, Erin Stewart, Renee V. Strong, Ellen Suh, Karena Sylvester, Reginald Thomas, Ni Ni Tint, Christopher Tsonis, Gary Wang, George Wang, Monica S. Williams, Sherita M. Williams, Sandra M. Windsor, Keriellen Wolfe, Mitchell M. Wu, Jayshree Zaveri, Kabir Chaturvedi, Andrei E. Gabrielian, Zhaoxi Ke, Jingtao Sun, Gangadharan Subramanian, and J. Craig Venter (31 May 2002) Science296 (5573), 1661.
[DOI: 10.1126/science.1069193] |Abstract »|Full Text »|PDF »|Supplemental Data »
