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Science 17 May 2002:
Vol. 296. no. 5571, pp. 1329 - 1330
DOI: 10.1126/science.296.5571.1329
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Tech.Sight

Understanding Disease Cell by Cell

Mark A. Rubin

The study of disease one cell at a time is being facilitated by advances in the field of tissue dissection. Using laser-guided microdissection tools coupled with a microscope, researchers can begin to understand molecular alterations in pure populations of cells. This essay discusses microdissection for an historical perspective and describes new approaches to the problem.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples.
G. Wang, C. Brennan, M. Rook, J. L. Wolfe, C. Leo, L. Chin, H. Pan, W.-H. Liu, B. Price, and G. M. Makrigiorgos (2004)
Nucleic Acids Res. 32, e76
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Science. ISSN 0036-8075 (print), 1095-9203 (online)