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Originally published in Science Express on 11 April 2002
Science 17 May 2002:
Vol. 296. no. 5571, pp. 1250 - 1251
DOI: 10.1126/science.1071808
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Perspectives

AGING:
Genomic Priorities in Aging

Paul Hasty and Jan Vijg

Many theories of aging have been proposed, but one of the most enduring is that expounding accumulated damage to the DNA as the root cause. In their Perspective, Hasty and Vijg comment on recent findings (de Boer et al.) in a mouse model of a human disease that point to imperfect repair of DNA damage over a lifetime as an important contributor to the cellular deterioration associated with aging.

P. Hasty is in the Department of Molecular Medicine and J. Vijg is in the Department of Physiology and Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA. J. Vijg is also at the Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA. E-mail: hastye{at}uthscsa.edu, vijg{at}uthscsa.edu

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