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Science 12 April 2002:
Vol. 296. no. 5566, pp. 269 - 270
DOI: 10.1126/science.1071207
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Perspectives

VIROLOGY:
Poliomyelitis Eradication--a Dangerous Endgame

Neal Nathanson and Paul Fine

Efforts to eradicate poliovirus from the face of the Earth have been very successful, thanks in large part to the oral poliovirus vaccine developed by Albert Sabin. However, as Nathanson and Fine explain in their Perspective, maintaining a world free from poliomyelitis will not be easy. They discuss the implications of a recent outbreak of paralytic poliomyelitis on the island of Hispaniola from which wild poliovirus was eliminated 10 years previously (Kew et al.).

N. Nathanson is in the Departments of Microbiology and Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. E-mail: nathansn{at}mail.med.upenn.edu P. Fine is at the London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK. E-mail: paul.fine{at}lshtm.ac.uk

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Can We Capitalize on the Virtues of Vaccines? Insights from the Polio Eradication Initiative.
R. B. Aylward and D. L. Heymann (2005)
Am J Public Health 95, 773-777
   Abstract »    Full Text »    PDF »
Ensuring Preparedness for Potential Poliomyelitis Outbreaks: Recommendations for the US Poliovirus Vaccine Stockpile From the National Vaccine Advisory Committee (NVAC) and the Advisory Committee on Immunization Practices (ACIP).
NVAC-ACIP Joint Working Group and Centers for Dise (2004)
Arch Pediatr Adolesc Med 158, 1106-1112
   Abstract »    Full Text »    PDF »
Circulation of Endemic Type 2 Vaccine-Derived Poliovirus in Egypt from 1983 to 1993.
C.-F. Yang, T. Naguib, S.-J. Yang, E. Nasr, J. Jorba, N. Ahmed, R. Campagnoli, H. van der Avoort, H. Shimizu, T. Yoneyama, et al. (2003)
J. Virol. 77, 8366-8377
   Abstract »    Full Text »    PDF »
Impaired Binding of Standard Initiation Factors Mediates Poliovirus Translation Attenuation.
K. Ochs, A. Zeller, L. Saleh, G. Bassili, Y. Song, A. Sonntag, and M. Niepmann (2002)
J. Virol. 77, 115-122
   Abstract »    Full Text »    PDF »
Polio Outbreaks Linked to Oral Vaccine.
(2002)
Journal Watch Infectious Diseases 2002, 4
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