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Science 22 March 2002:
Vol. 295. no. 5563, pp. 2221 - 2222
DOI: 10.1126/science.1071285
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Perspectives

MOLECULAR BIOLOGY:
Skiing Toward Nonstop mRNA Decay

Lynne E. Maquat

Prokaryotic and eukaryotic cells have quality assurance mechanisms that operate during translation to prevent buildup of deleterious protein products. In her Perspective, Maquat discusses new work (Frischmeyer et al. and van Hoof et al.) that describes how eukaryotic cells identify and degrade messenger RNA that lacks a termination codon.

The author is in the Department of Biochemistry and Biophysics, School of Medicine and Dentistry, University of Rochester, 601 Elmwood Avenue, Box 712, Rochester, NY 14642, USA. E-mail: lynne_maquat{at}urmc.rochester.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure of Yeast Dom34: A PROTEIN RELATED TO TRANSLATION TERMINATION FACTOR Erf1 AND INVOLVED IN No-Go DECAY.
M. Graille, M. Chaillet, and H. van Tilbeurgh (2008)
J. Biol. Chem. 283, 7145-7154
   Abstract »    Full Text »    PDF »
Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.
O. Isken and L. E. Maquat (2007)
Genes & Dev. 21, 1833-3856
   Abstract »    Full Text »    PDF »
From Birth to Death: The Complex Lives of Eukaryotic mRNAs.
M. J. Moore (2005)
Science 309, 1514-1518
   Abstract »    Full Text »    PDF »
ENAM Mutations in Autosomal-dominant Amelogenesis Imperfecta.
J.-W. Kim, F. Seymen, B.P.-J. Lin, B. Kiziltan, K. Gencay, J.P. Simmer, and J.C.-C. Hu (2005)
Journal of Dental Research 84, 278-282
   Abstract »    Full Text »    PDF »
MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta.
J-W Kim, J P Simmer, T C Hart, P S Hart, M D Ramaswami, J D Bartlett, and J C-C Hu (2005)
J. Med. Genet. 42, 271-275
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MRE11 mutations and impaired ATM-dependent responses in an Italian family with ataxia-telangiectasia-like disorder.
D. Delia, M. Piane, G. Buscemi, C. Savio, S. Palmeri, P. Lulli, L. Carlessi, E. Fontanella, and L. Chessa (2004)
Hum. Mol. Genet. 13, 2155-2163
   Abstract »    Full Text »    PDF »
Nuclear surveillance and degradation of hypomodified initiator tRNAMet in S. cerevisiae.
S. Kadaba, A. Krueger, T. Trice, A. M. Krecic, A. G. Hinnebusch, and J. Anderson (2004)
Genes & Dev. 18, 1227-1240
   Abstract »    Full Text »    PDF »
The Chironomus tentans translation initiation factor eIF4H is present in the nucleus but does not bind to mRNA until the mRNA reaches the cytoplasmic perinuclear region.
P. Bjork, G. Bauren, B. Gelius, O. Wrange, and L. Wieslander (2003)
J. Cell Sci. 116, 4521-4532
   Abstract »    Full Text »    PDF »
SsrA-mediated trans-translation plays a role in mRNA quality control by facilitating degradation of truncated mRNAs.
Y. YAMAMOTO, T. SUNOHARA, K. JOJIMA, T. INADA, and H. AIBA (2003)
RNA 9, 408-418
   Abstract »    Full Text »    PDF »
Functional Analysis of a Divergent System II Protein, Ccs1, Involved in c-Type Cytochrome Biogenesis.
B. W. Dreyfuss, P. P. Hamel, S. S. Nakamoto, and S. Merchant (2003)
J. Biol. Chem. 278, 2604-2613
   Abstract »    Full Text »    PDF »
An Alternate Translation Initiation Site Circumvents an Amino-Terminal DAX1 Nonsense Mutation Leading to a Mild Form of X-Linked Adrenal Hypoplasia Congenita.
G. Ozisik, G. Mantovani, J. C. Achermann, L. Persani, A. Spada, J. Weiss, P. Beck-Peccoz, and J. L. Jameson (2003)
J. Clin. Endocrinol. Metab. 88, 417-423
   Abstract »    Full Text »    PDF »


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