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Science 1 March 2002:
Vol. 295. no. 5560, pp. 1654 - 1655
DOI: 10.1126/science.1070127
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Perspectives

CELL BIOLOGY:
A Pit Stop at the ER

Gordon N. Gill

Although ligand activation of receptor signaling is well understood, less is known about how a cell switches off signaling by the activated receptor. In his Perspective, Gill discusses new work (Haj et al.) that visualizes one step in the process of deactivating a ligand-activated receptor tyrosine kinase--the dephosphorylation of the internalized receptor by a phosphatase in the endoplasmic reticulum.

The author is at the University of California, San Diego, La Jolla, CA 92093-0650, USA. E-mail: ggill{at}ucsd.edu

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