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Science 1 March 2002:
Vol. 295. no. 5560, pp. 1651 - 1653
DOI: 10.1126/science.1070163
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Perspectives

NEUROBIOLOGY:
Does BDNF Have Pre- or Postsynaptic Targets?

Toshiya Manabe

A type of synaptic plasticity in the brain called long-term potentiation (LTP) is thought to form the molecular basis of learning and memory. In a Perspective, Manabe discusses new findings (Kovalchuk et al.) showing brain-derived neurotropic factor modulates LTP by binding to TrkB receptors on the postsynaptic neuron.

The author is in the Division of Cell Biology and Neurophysiology, Department of Neuroscience, Faculty of Medicine, Kobe University, Kobe 650-0017, Japan, and Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. E-mail: tmanabe-tky{at}umin.ac.jp

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Neurotrophin-Mediated Rapid Signaling in the Central Nervous System: Mechanisms and Functions.
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BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes.
E. Palma, G. Torchia, C. Limatola, F. Trettel, A. Arcella, G. Cantore, G. Di Gennaro, M. Manfredi, V. Esposito, P. P. Quarato, et al. (2005)
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A Novel Mechanism for the Facilitation of Theta-Induced Long-Term Potentiation by Brain-Derived Neurotrophic Factor.
E. A. Kramar, B. Lin, C.-Y. Lin, A. C. Arai, C. M. Gall, and G. Lynch (2004)
J. Neurosci. 24, 5151-5161
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Activation of Adenosine A2A Receptor Facilitates Brain-Derived Neurotrophic Factor Modulation of Synaptic Transmission in Hippocampal Slices.
M. J. Diogenes, C. C. Fernandes, A. M. Sebastiao, and J. A. Ribeiro (2004)
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Plasticity in Respiratory Motor Control: Invited Review: Neuroplasticity in respiratory motor control.
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