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The goals of cloning--to create a genetically identical copy of a biological entity--is substantially different from that of making stem cells for regenerative medicine, although both may use the somatic cell nuclear transfer technique. The use of the term "therapeutic cloning" for producing stem cells is misleading and blurs the distinction between the objectives of these two very different lines of investigation. Vogelstein et al. recommend adopting the term "nuclear transplantation" in relation to stem cell research would be more precise and would emphasize the difference in purpose between production of stem cells and "cloning" to produce a copy of a human being.
B. Vogelstein is at the Howard Hughes Medical Institute, and the Kimmel Cancer Center at Johns Hopkins University, Baltimore, MD 21231, USA and chaired the recent National Research Council report on stem cells. B. Alberts is president, National Academy of Sciences, and chair, National Research Council; Washington, DC 20418, USA. K. Shine is president, Institute of Medicine; Washington, DC 20418, USA.
*To whom correspondence should be addressed. E-mail: vogelbe{at}welch.jhu.edu
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