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Glaucoma, a disease that results in progressive loss of peripheral vision, is a principal cause of blindness worldwide. In their Perspective, Friedman and Walter describe new findings (Rezaie et al.) that identify mutations in a gene encoding the optineurin protein in a significant number of patients with primary open-angle glaucoma. This discovery may help us to better understand what causes glaucoma, eventually leading to therapeutic interventions to treat this tragic disease.
The authors are in the Departments of Ophthalmology and Medical Genetics, University of Alberta, Edmonton, T6G 2S2 Alberta, Canada. E-mail: mwalter{at}ualberta.ca
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REPORTS
Tayebeh Rezaie, Anne Child, Roger Hitchings, Glen Brice, Lauri Miller, Miguel Coca-Prados, Elise Héon, Theodore Krupin, Robert Ritch, Donald Kreutzer, R. Pitts Crick, and Mansoor Sarfarazi (8 February 2002) Science295 (5557), 1077.
[DOI: 10.1126/science.1066901] |Abstract »|Full Text »|PDF »|Supplemental Data »
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