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Science 8 February 2002:
Vol. 295. no. 5557, p. 1033
DOI: 10.1126/science.295.5557.1033
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Cracking the Secrets of Aging

Constance Holden

Theories about how to define aging abound, including the accumulation of cell damage and the stiffening of tissue with formation of sugar-protein bonds. Another is the progressive shortening of telomeres, the tips of chromosomes, as cells divide. Scientists are still not even sure whether aging is in fact a unitary phenomenon. Meanwhile, the life-extending effect of calorie restriction offers researchers tantalizing clues.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)