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NEUROBIOLOGY: Learning More About NMDA Receptor Regulation
Anirvan Ghosh
Increased calcium permeability of the NMDA receptors of postsynaptic neurons influences synaptic plasticity and, hence, learning and memory. In a Perspective, Ghosh explains new findings (Takasu et al.) that reveal how the NMDA receptor-mediated postsynaptic calcium influx is regulated by activation of the EphB receptor and its signaling pathway.
The author is in the Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: aghosh{at}jhmi.edu
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In Science Magazine
REPORTS
Mari A. Takasu, Matthew B. Dalva, Richard E. Zigmond, and Michael E. Greenberg (18 January 2002) Science295 (5554), 491.
[DOI: 10.1126/science.1065983] |Abstract »|Full Text »|PDF »|Supplemental Data »
Ligand Binding and Calcium Influx Induce Distinct Ectodomain/{gamma}-Secretase-processing Pathways of EphB2 Receptor.
C. Litterst, A. Georgakopoulos, J. Shioi, E. Ghersi, T. Wisniewski, R. Wang, A. Ludwig, and N. K. Robakis (2007)
J. Biol. Chem.
282, 16155-16163
|Abstract »|Full Text »|PDF »
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth.
N. Kertesz, V. Krasnoperov, R. Reddy, L. Leshanski, S. R. Kumar, S. Zozulya, and P. S. Gill (2006)
Blood
107, 2330-2338
|Abstract »|Full Text »|PDF »
