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Science 18 January 2002:
Vol. 295. no. 5554, p. 422
DOI: 10.1126/science.295.5554.422a
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News of the Week

CELL BIOLOGY:
Stripping the Nucleolus Down to Its Proteins

Jennifer Couzin

Scientists have identified 271 proteins in a compartment of the cell nucleus called the nucleolus--a first step toward fully deciphering this organelle, a critical element in the construction of ribosomes, which go on to make proteins. With scientists now debating the nucleolus's role in additional functions, including cell cycle regulation and gene silencing, this starter list of proteins--30% of which are uncharacterized--offers plenty to chew on.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)