Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 January 2002:
Vol. 295. no. 5553, pp. 284 - 287
DOI: 10.1126/science.1068664
Prev | Table of Contents | Next

Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

PROTEOMICS:
Enhanced: Integrating Interactomes

Mark Gerstein, Ning Lan, Ronald Jansen

In the postgenomic era, working out which proteins interact with each other will be important for finding out what each protein does. In their Perspective, Gerstein et al. describe new work (Tong et al.) that combines two completely different data sets to work out which yeast proteins interact and which peptide recognition domains are involved.

The authors are in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. E-mail: mark.gerstein{at}yale.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human Endoplasmic Reticulum Mannosidase I Is Subject to Regulated Proteolysis.
Y. Wu, D. J. Termine, M. T. Swulius, K. W. Moremen, and R. N. Sifers (2007)
J. Biol. Chem. 282, 4841-4849
   Abstract »    Full Text »    PDF »
Bacterial Postgenomics: the Promise and Peril of Systems Biology{triangledown}.
G. Suen, J. S. Jakobsen, B. S. Goldman, M. Singer, A. G. Garza, and R. D. Welch (2006)
J. Bacteriol. 188, 7999-8004
   Full Text »    PDF »
Assessing the limits of genomic data integration for predicting protein networks.
L. J. Lu, Y. Xia, A. Paccanaro, H. Yu, and M. Gerstein (2005)
Genome Res. 15, 945-953
   Abstract »    Full Text »    PDF »
Lack of Myoglobin Causes a Switch in Cardiac Substrate Selection.
U. Flogel, T. Laussmann, A. Godecke, N. Abanador, M. Schafers, C. D. Fingas, S. Metzger, B. Levkau, C. Jacoby, and J. Schrader (2005)
Circ. Res. 96, e68-e75
   Abstract »    Full Text »    PDF »
From Gene Networks to Gene Function.
T. Schlitt, K. Palin, J. Rung, S. Dietmann, M. Lappe, E. Ukkonen, and A. Brazma (2003)
Genome Res. 13, 2568-2576
   Abstract »    Full Text »    PDF »
Protein complexes and functional modules in molecular networks.
V. Spirin and L. A. Mirny (2003)
PNAS 100, 12123-12128
   Abstract »    Full Text »    PDF »
Modeling the Heart--from Genes to Cells to the Whole Organ.
D. Noble (2002)
Science 295, 1678-1682
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)