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Also see the archival list of Science's Compass: Enhanced Perspectives
DNA REPLICATION: Enhanced: Genomic Views of Genome Duplication
Bruce Stillman
DNA replication is initiated at numerous origins of replication (oris) within the chromosomes. In a pair of ambitious studies, two groups have used different techniques to pinpoint the locations of all of the oris throughout the yeast genome at different times during S phase (Raghuraman et al., Wyrick et al.). Stillman, in his Perspective, compares and contrasts the different methods and their findings, and speculates on the value of combining these techniques to look at oris in the human genome.
The author is at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. E-mail: stillman{at}cshl.org
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In Science Magazine
REPORTS
John J. Wyrick, Jennifer G. Aparicio, Ting Chen, John D. Barnett, Ezra G. Jennings, Richard A. Young, Stephen P. Bell, and Oscar M. Aparicio (14 December 2001) Science294 (5550), 2357.
[DOI: 10.1126/science.1066101] |Abstract »|Full Text »|PDF »|Supplemental Data »
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