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Science 14 December 2001:
Vol. 294. no. 5550, pp. 2299 - 2300
DOI: 10.1126/science.1067850
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Perspectives

VIROLOGY:
The X Files--One Step Closer to Closure

Don Ganem

There may be drugs and a useful vaccine available to combat the hepatitis B virus, but one aspect of this pathogen remains a puzzle: the function of its HBx protein. As Ganem reveals in his Perspective, new findings (Bouchard et al.) show that this versatile viral protein is an activator of calcium-dependent Ras signaling, an observation that may explain many of its biological effects.

The author is at the Howard Hughes Medical Institute, Departments of Medicine and Microbiology, University of California, San Francisco, CA 94143, USA. E-mail: ganem{at}cgl.ucsf.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Deregulated Direct Targets of the Hepatitis B Virus (HBV) Protein, HBx, Identified through Chromatin Immunoprecipitation and Expression Microarray Profiling.
W.-K. Sung, Y. Lu, C. W. H. Lee, D. Zhang, M. Ronaghi, and C. G. L. Lee (2009)
J. Biol. Chem. 284, 21941-21954
   Abstract »    Full Text »    PDF »
Mechanisms for Inhibition of Hepatitis B Virus Gene Expression and Replication by Hepatitis C Virus Core Protein.
S.-Y. Chen, C.-F. Kao, C.-M. Chen, C.-M. Shih, M.-J. Hsu, C.-H. Chao, S.-H. Wang, L.-R. You, and Y.-H. W. Lee (2003)
J. Biol. Chem. 278, 591-607
   Abstract »    Full Text »    PDF »
Kaposi's Sarcoma-Associated Herpesvirus Mitochondrial K7 Protein Targets a Cellular Calcium-Modulating Cyclophilin Ligand To Modulate Intracellular Calcium Concentration and Inhibit Apoptosis.
P. Feng, J. Park, B.-S. Lee, S.-H. Lee, R. J. Bram, and J. U. Jung (2002)
J. Virol. 76, 11491-11504
   Abstract »    Full Text »    PDF »


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