Related Content
Search Google Scholar for:
More Information
Related Jobs from ScienceCareers
|
|
Science 14 December 2001:
Vol. 294. no. 5550, p. 2245
DOI: 10.1126/science.294.5550.2245k
|
|
This Week in Science
Hepatitis B virus (HBV) infects 300 million people worldwide and causes liver disease and cancer. The X-protein of HBV is essential for viral infection and has been implicated in carcinogenesis, but its exact role has been enigmatic. It is known to infiltrate cell signaling pathways and activate modest transcription from various promoters, as well as strongly activate viral replication in certain cell lines. The X-protein activates Src kinase without interacting directly with Src. Bouchard et al. (p. 2376; see the Perspective by Ganem) have now discovered that this activation is mediated by the activation of another kinase called Pyk. The activation of Pyk is caused by a release of calcium from intracellular stores (most likely the mitochondrion) triggered by the X-protein.
|
|
Science. ISSN 0036-8075 (print), 1095-9203 (online)
