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STEM CELLS: PTEN--Coupling Tumor Suppression to Stem Cells?
Josef M. Penninger and James Woodgett
Mutations in the tumor suppressor protein PTEN are found in many different tumors. As Penninger and Woodgett discuss in their Perspective, new findings implicate PTEN in the control of neuronal cell size and in the proliferation and self-renewal of neuronal stem cells (Groszer et al.). This surprising finding may yield both research and therapeutic benefits.
J. M. Penninger is at Amgen Research Institute and J. Woodgett is at the Ontario Cancer Institute, University of Toronto, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada. E-mail: jpenning{at}amgen.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Matthias Groszer, Rebecca Erickson, Deirdre D. Scripture-Adams, Ralf Lesche, Andreas Trumpp, Jerome A. Zack, Harley I. Kornblum, Xin Liu, and Hong Wu (7 December 2001) Science294 (5549), 2186.
[DOI: 10.1126/science.1065518] |Abstract »|Full Text »|PDF »|Supplemental Data »
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