Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Active Motif, Inc.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 7 December 2001:
Vol. 294. no. 5549, pp. 2113 - 2115
DOI: 10.1126/science.1066726
Prev | Table of Contents | Next

Perspectives

MOLECULAR BIOLOGY:
Methylation Talk Between Histones and DNA

Adrian Bird

The addition of methyl groups to DNA or histones is a way to directly or indirectly silence gene expression. Although the two events are conceivably connected, they have always been studied separately. In his Perspective, Bird explores the exciting notion (supported by data published elsewhere) that the two events are irrevocably linked, that is, DNA methylation depends on histone methylation.

The author is at the Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Edinburgh EH9 3JR, UK. E-mail: a.bird{at}ed.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells.
Q. Zhou, A. T. Agoston, P. Atadja, W. G. Nelson, and N. E. Davidson (2008)
Mol. Cancer Res. 6, 873-883
   Abstract »    Full Text »    PDF »
Oxidative stress and redox regulation of lung inflammation in COPD..
I. Rahman and I. M. Adcock (2006)
Eur. Respir. J. 28, 219-242
   Abstract »    Full Text »    PDF »
Enhancement of Sleeping Beauty Transposition by CpG Methylation: Possible Role of Heterochromatin Formation.
K. Yusa, J. Takeda, and K. Horie (2004)
Mol. Cell. Biol. 24, 4004-4018
   Abstract »    Full Text »    PDF »
Eukaryotic Methyl-CpG-Binding Domain Proteins and Chromatin Modification.
M.-S. Hung and C.-K. J. Shen (2003)
Eukaryot. Cell 2, 841-846
   Full Text »    PDF »
Viral Genes and Methylation.
M. VERMA (2003)
Ann. N.Y. Acad. Sci. 983, 170-180
   Abstract »    Full Text »    PDF »
Early Detection and Risk Assessment Proceedings and Recommendations from the Workshop on Epigenetics in Cancer Prevention.
M. VERMA, B. K. DUNN, S. ROSS, P. JAIN, W. WANG, R. HAYES, and A. UMAR (2003)
Ann. N.Y. Acad. Sci. 983, 298-319
   Abstract »    Full Text »    PDF »
Definitions in Epigenetics.
(2003)
Ann. N.Y. Acad. Sci. 983, 321-328
   Full Text »    PDF »
Hemoglobinopathies.
G. F. Atweh, J. DeSimone, Y. Saunthararajah, H. Fathallah, R. S. Weinberg, R. L. Nagel, M. E. Fabry, and R. J. Adams (2003)
Hematology 2003, 14-39
   Abstract »    Full Text »    PDF »
Exposure to UV light causes increased biotinylation of histones in Jurkat cells.
D. M. Peters, J. B. Griffin, J. S. Stanley, M. M. Beck, and J. Zempleni (2002)
Am J Physiol Cell Physiol 283, C878-C884
   Abstract »    Full Text »    PDF »


ADVERTISEMENT
Click Me!

ADVERTISEMENT
Click Me!

To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)