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Science 7 December 2001:
Vol. 294. no. 5549, pp. 2074 - 2077
DOI: 10.1126/science.294.5549.2074
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News Focus

PROTEOMICS:
High-Speed Biologists Search for Gold in Proteins

Robert F. Service

Proteomics aims to chart the ebb and flow of tens of thousands of proteins at once to produce snapshots of life inside cells. The technology to pull it off doesn't exist yet, however, and the competition is stiff for those proteins that can be nabbed using current methods. But this young field is growing up fast. This special News Focus looks at the promise and roadblocks of biology's latest wellspring. The package includes profiles of GeneProt, the biggest proteomics test-bed to date, and Stephen Burley, a crystallographer who is leaving academia to direct research at a small start-up company. Other stories discuss the potential of protein chips for new diagnostics and research tools and the problems faced by companies attempting to patent proteins.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Perspective: Proteomics--See "Spots" Run.
J. J. Kopchick, E. O. List, D. T. Kohn, G. M. O. Keidan, L. Qiu, and S. Okada (2002)
Endocrinology 143, 1990-1994
   Abstract »    Full Text »    PDF »
Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue.
S. K. Sze, Y. Ge, H. Oh, and F. W. McLafferty (2002)
PNAS
   Abstract »    Full Text »    PDF »
From the Cover: Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue.
S. K. Sze, Y. Ge, H. Oh, and F. W. McLafferty (2002)
PNAS 99, 1774-1779
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)