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Science 30 November 2001:
Vol. 294. no. 5548, pp. 1845 - 1847
DOI: 10.1126/science.1067418
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Perspectives

SIGNAL TRANSDUCTION:
A New Thread in an Intricate Web

Mark von Zastrow and Keith Mostov

Understanding how biochemical pathways are connected in the cell is one of the big challenges facing cell biologists. In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events.

The authors are in the Program in Cell Biology, Departments of Psychiatry, Cellular and Molecular Pharmacology, Anatomy, and Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA. E-mail: zastrow{at}itsa.ucsf.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cellular Regulation of RGS Proteins: Modulators and Integrators of G Protein Signaling.
S. Hollinger and J. R. Hepler (2002)
Pharmacol. Rev. 54, 527-559
   Abstract »    Full Text »    PDF »
Heterotrimeric and Unconventional GTP Binding Proteins in Plant Cell Signaling.
S. M. Assmann (2002)
PLANT CELL 14, S355-373
   Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)