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Science 30 November 2001:
Vol. 294. no. 5548, p. 1785
DOI: 10.1126/science.294.5548.1785g
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This Week in Science
Intestinal intraepithelial lymphocytes (IELs) reside at epithelial surface along the gut, and many members of this class of T cells express a homotypic form of the CD8a molecule whose role had been unexplained in the context of IEL biology. Leishman et al. (p. 1936; see the Perspective by Lambolez and Rocha ) show that CD8aa homodimers interact specifically with a major histocompatibility complex-like molecule, termed TL, expressed on intestinal epithelial cells. When CD8aa engaged TL, cell division and cytokine production of antigen-specific IEL were increased, and other effector functions, such as cytotoxic activity, were inhibited. Thus, CD8aa may not act as a typical coreceptor but rather as a regulatory molecule that modulates that activity of intestinal T cells
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Science. ISSN 0036-8075 (print), 1095-9203 (online)
