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Science 23 November 2001:
Vol. 294. no. 5547, pp. 1638 - 1642
DOI: 10.1126/science.294.5547.1638
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News Focus

GENE THERAPY:
Safer and Virus-Free?

Dan Ferber

Most nonviral vectors for gene therapy fly under the radar of the immune system, and they're cheaper and easier to manufacture than viral vectors. But most of them have not been as efficient as viruses in shuttling genes into cells, and the genes that were delivered didn't remain active for long. In the past few years, though, that has begun to change.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Phospholipid-Based Artificial Viruses Assembled by Multivalent Cations.
G. Tresset, W. C. D. Cheong, Y. L. S. Tan, J. Boulaire, and Y. M. Lam (2007)
Biophys. J. 93, 637-644
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Computational and Analytical Modeling of Cationic Lipid-DNA Complexes.
O. Farago and N. Gronbech-Jensen (2007)
Biophys. J. 92, 3228-3240
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Adenovirus Fiber Shaft Contains a Trimerization Element That Supports Peptide Fusion for Targeted Gene Delivery.
J. Li, S. Lad, G. Yang, Y. Luo, M. Iacobelli-Martinez, F. J. Primus, R. A. Reisfeld, and E. Li (2006)
J. Virol. 80, 12324-12331
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Direct Evidence of Multicompartment Aggregates in Polyelectrolyte-Charged Liposome Complexes.
F. Bordi, C. Cametti, S. Sennato, and M. Diociaiuti (2006)
Biophys. J. 91, 1513-1520
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Effect of Cell Electroporation on the Conductivity of a Cell Suspension.
M. Pavlin, M. Kanduser, M. Rebersek, G. Pucihar, F. X. Hart, R. Magjarevic, and D. Miklavcic (2005)
Biophys. J. 88, 4378-4390
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Pulsed High-Intensity Focused Ultrasound Enhances Systemic Administration of Naked DNA in Squamous Cell Carcinoma Model: Initial Experience.
K. M. Dittmar, J. Xie, F. Hunter, C. Trimble, M. Bur, V. Frenkel, and K. C. P. Li (2005)
Radiology 235, 541-546
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Ribozymes: Applications to Functional Analysis and Gene Discovery.
M. Shiota, M. Sano, M. Miyagishi, and K. Taira (2004)
J. Biochem. 136, 133-147
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Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes.
A. J. Lin, N. L. Slack, A. Ahmad, C. X. George, C. E. Samuel, and C. R. Safinya (2003)
Biophys. J. 84, 3307-3316
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Antibody-Mediated Targeting of an Adenovirus Vector Modified To Contain a Synthetic Immunoglobulin G-Binding Domain in the Capsid.
C. Volpers, C. Thirion, V. Biermann, S. Hussmann, H. Kewes, P. Dunant, H. von der Mark, A. Herrmann, S. Kochanek, and H. Lochmuller (2003)
J. Virol. 77, 2093-2104
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Retrovirus-Mediated Modification of Male Germline Stem Cells in Rats.
K. E. Orwig, M. R. Avarbock, and R. L. Brinster (2002)
Biol Reprod 67, 874-879
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Defining Gene Transfer Before Expecting Gene Therapy: Putting the Horse Before the Cart.
S. Pislaru, S. P. Janssens, B. J. Gersh, and R. D. Simari (2002)
Circulation 106, 631-636
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Science. ISSN 0036-8075 (print), 1095-9203 (online)