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Science 23 November 2001:
Vol. 294. no. 5547, pp. 1638 - 1642
DOI: 10.1126/science.294.5547.1638
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News Focus

GENE THERAPY:
Safer and Virus-Free?

Dan Ferber

Most nonviral vectors for gene therapy fly under the radar of the immune system, and they're cheaper and easier to manufacture than viral vectors. But most of them have not been as efficient as viruses in shuttling genes into cells, and the genes that were delivered didn't remain active for long. In the past few years, though, that has begun to change.

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Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications.
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Ribozymes: Applications to Functional Analysis and Gene Discovery.
M. Shiota, M. Sano, M. Miyagishi, and K. Taira (2004)
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Antibody-Mediated Targeting of an Adenovirus Vector Modified To Contain a Synthetic Immunoglobulin G-Binding Domain in the Capsid.
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Retrovirus-Mediated Modification of Male Germline Stem Cells in Rats.
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Defining Gene Transfer Before Expecting Gene Therapy: Putting the Horse Before the Cart.
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