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Science 16 November 2001:
Vol. 294. no. 5546, p. 1413
DOI: 10.1126/science.294.5546.1413i
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Alpha particles are high-energy helium nuclei that are extremely potent cell-killing agents. Monoclonal antibody-mediated targeting of these particles to tumor cells has been investigated as an anticancer therapy, but the short half-life of the particles has limited the success of this approach. McDevitt et al. (p. 1537) developed a molecular-sized generator that produces atoms that emit alpha particles and then targeted the generator itself to the tumor cells. Treatment of mice bearing solid or disseminated cancers with a single nanocurie level dose of these constructs induced durable tumor regressions. In principle, such atomic "nanogenerators" could be used for treatment of a wide range of human cancers.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)