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IMMUNOLOGY: Antigen Presentation--Losing Its Shine in the Absence of GILT
Colin Watts
T cell activation requires presentation of antigen by antigen-presenting cells (APCs). Before the antigen can be presented on the APC surface, it must be processed within the endosomes and lysosomes of APCs into short peptides, which are then assembled into complexes with MHC class II molecules. In a Perspective, Watts identifies the enzyme GILT as a necessary component for efficient processing of antigen containing disulfide bonds (Maric et al.).
The author is in the School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. E-mail: c.watts{at}dundee.ac.uk
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REPORTS
Maja Maric, Balasubramanian Arunachalam, Uyen T. Phan, Chen Dong, Wendy S. Garrett, Kurt S. Cannon, Christopher Alfonso, Lars Karlsson, Richard A. Flavell, and Peter Cresswell (9 November 2001) Science294 (5545), 1361.
[DOI: 10.1126/science.1065500] |Abstract »|Full Text »|PDF »|Supplemental Data »
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