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Science 2 November 2001:
Vol. 294. no. 5544, p. 985
DOI: 10.1126/science.294.5544.985
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News Focus
BIOTERRORISM:
Smallpox Vaccinations: How Much Protection Remains?
Jon Cohen
Immunity from smallpox vaccination is widely assumed to decline rapidly, and those vaccinated 30 or more years ago are now
unprotected. But a handful of researchers who have examined the scientific literature, including century-old studies as
well as state-of-the-art explorations of immunologic memory, believe protection may be far more durable.
Read the Full Text
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- J. Martinez, X. Huang, and Y. Yang (2008)
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- L. P. Perera, T. A. Waldmann, J. D. Mosca, N. Baldwin, J. A. Berzofsky, and S.-K. Oh (2007)
J. Virol.
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- Persisting Humoral Antiviral Immunity within the Japanese Population after the Discontinuation in 1976 of Routine Smallpox Vaccinations.
- S. Hatakeyama, K. Moriya, M. Saijo, Y. Morisawa, I. Kurane, K. Koike, S. Kimura, and S. Morikawa (2005)
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- Distinct Time Effects of Vaccination on Long-Term Proliferative and IFN-{gamma}-producing T Cell Memory to Smallpox in Humans.
- B. Combadiere, A. Boissonnas, G. Carcelain, E. Lefranc, A. Samri, F. Bricaire, P. Debre, and B. Autran (2004)
J. Exp. Med.
199, 1585-1593
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- The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro.
- J. D. Kahmann, D. A. Wecking, V. Putter, K. Lowenhaupt, Y.-G. Kim, P. Schmieder, H. Oschkinat, A. Rich, and M. Schade (2004)
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101, 2712-2717
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- Analysis of Historical Data Suggests Long-lasting Protective Effects of Smallpox Vaccination.
- M. Eichner (2003)
Am. J. Epidemiol.
158, 717-723
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- Case Isolation and Contact Tracing Can Prevent the Spread of Smallpox.
- M. Eichner (2003)
Am. J. Epidemiol.
158, 118-128
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- Smallpox: The Main Site of Transmission is the Oropharynx.
- S. Baron (2003)
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- Evaluation of 21st-Century Risks of Smallpox Vaccination and Policy Options.
- J. M. Lane and J. Goldstein (2003)
Ann Intern Med
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- The Public and the Smallpox Threat.
- R. J. Blendon, C. M. DesRoches, J. M. Benson, M. J. Herrmann, K. Taylor-Clark, and K. J. Weldon (2003)
N. Engl. J. Med.
348, 426-432
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- Responses to Smallpox Vaccine.
- M. A. Sauri, J. A. Frelinger, M. L. Garba, R. B. Belshe, and S. E. Frey (2002)
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347, 689-690
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- The Case for Voluntary Smallpox Vaccination.
- W. J. Bicknell (2002)
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346, 1323-1325
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- The Case for Voluntary Smallpox Vaccination.
- W. J. Bicknell (2002)
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