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Also see the archival list of Science's Compass: Enhanced Perspectives
DEVELOPMENT: Enhanced: Endothelium--Chicken Soup for the Endoderm
Nathan Bahary and Leonard I. Zon
Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas (Matsumoto et al., Lammert et al.).
N. Bahary is in the Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. L. I. Zon is in the Department of Hematology/Oncology, Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA. E-mail: zon{at}genetics.med.harvard.edu
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In Science Magazine
RESEARCH ARTICLES
Kunio Matsumoto, Hideyuki Yoshitomi, Janet Rossant, and Kenneth S. Zaret (19 October 2001) Science294 (5542), 559.
[DOI: 10.1126/science.1063889] |Abstract »|Full Text »|PDF »|Supplemental Data »
An Illustrated Review of Early Pancreas Development in the Mouse.
M. C. Jorgensen, J. Ahnfelt-Ronne, J. Hald, O. D. Madsen, P. Serup, and J. Hecksher-Sorensen (2007)
Endocr. Rev.
28, 685-705
|Abstract »|Full Text »|PDF »
Arachidonic Acid Predominates in the Membrane Phosphoglycerides of the Early and Term Human Placenta.
D. Bitsanis, M. A. Crawford, T. Moodley, H. Holmsen, K. Ghebremeskel, and O. Djahanbakhch (2005)
J. Nutr.
135, 2566-2571
|Abstract »|Full Text »|PDF »
Angiopoietin-1 Causes Reversible Degradation of the Portal Microcirculation in Mice: Implications for Treatment of Liver Disease.
N. L. Ward, A. L. Haninec, P. Van Slyke, J. G. Sled, C. Sturk, R. M. Henkelman, I. R. Wanless, and D. J. Dumont (2004)
Am. J. Pathol.
165, 889-899
|Abstract »|Full Text »|PDF »
Visualization of Lymphotoxin-{beta} and Lymphotoxin-{beta} Receptor Expression in Mouse Embryos.
