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SIGNAL TRANSDUCTION: Calcium Channels--Link Locally, Act Globally
Stephen R. Ikeda
Ca2+-dependent gene transcription and L-type Ca2+ channel inactivation share a common initiating event. As Ikeda explains in his Perspective, in each case, local increases in [Ca2+] result in binding to calmodulin that is tethered to the Ca2+ channel protein. An accompanying conformational change triggers phosphorylation of the transcription factor CREB and closure, or inactivation, of L-type Ca2+ channels (Dolmetsch et al.).
The author is in the Laboratory of Molecular Physiology, Guthrie Research Institute, Sayre, PA 18840, USA. E-mail: sikeda{at}inet.guthrie.org
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In Science Magazine
RESEARCH ARTICLES
Ricardo E. Dolmetsch, Urvi Pajvani, Katherine Fife, James M. Spotts, and Michael E. Greenberg (12 October 2001) Science294 (5541), 333.
[DOI: 10.1126/science.1063395] |Abstract »|Full Text »|PDF »
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Functional Stoichiometry and Local Enrichment of Calmodulin Interacting with Ca2+ Channels.
