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Cyclin E and its kinase partner CDK2 are essential for initiating duplication of the genome during S phase of the cell cycle. But how is cyclin E itself regulated? In a comprehensive Perspective, Bartek and Lukas describe new findings in this issue (Koepp et al.) and elsewhere that identify an F-box protein called Fbw7/hCdc4/Ago as the controller of cyclin E degradation. Intriguingly, mutations in this F-box protein are associated with some forms of breast and ovarian cancer.
The authors are at the Institute of Cancer Biology, Danish Cancer Society, DK-2100 Copenhagen, Denmark. E-mail: bartek{at}biobase.dk
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In Science Magazine
REPORTS
Deanna M. Koepp, Laura K. Schaefer, Xin Ye, Khandan Keyomarsi, Claire Chu, J. Wade Harper, and Stephen J. Elledge (5 October 2001) Science294 (5540), 173.
[DOI: 10.1126/science.1065203] |Abstract »|Full Text »|PDF »|Supplemental Data »
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