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Science 21 September 2001:
Vol. 293. no. 5538, pp. 2192 - 2194
DOI: 10.1126/science.293.5538.2192
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News Focus

NEUROSCIENCE:
New Leads on the 'How' of Alzheimer's

Jean Marx

Although the idea is still controversial, evidence is mounting that triggers for Alzheimer's disease kill neurons by activating their internal cell-death programs. Working with a variety of experimental systems, including brain samples taken from patients at autopsy, researchers have found several signs that the cellular machinery involved in apoptosis has been activated in Alzheimer's. Not everyone agrees that nerve cells die this way in Alzheimer's, but if the findings are confirmed, they could provide new targets for drugs aimed at slowing the progression of Alzheimer's, or even preventing it.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
p53-dependent Aph-1 and Pen-2 Anti-apoptotic Phenotype Requires the Integrity of the {gamma}-Secretase Complex but Is Independent of Its Activity.
J. Dunys, T. Kawarai, J. Sevalle, V. Dolcini, P. St. George-Hyslop, C. A. Da Costa, and F. Checler (2007)
J. Biol. Chem. 282, 10516-10525
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Aluminum-Maltolate Induces Apoptosis and Necrosis in Neuro-2a Cells: Potential Role for p53 Signaling.
V. J. Johnson, S.-H. Kim, and R. P. Sharma (2005)
Toxicol. Sci. 83, 329-339
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Glycogen Synthase Kinase 3{beta} Induces Caspase-cleaved Tau Aggregation in Situ.
J.-H. Cho and G. V. W. Johnson (2004)
J. Biol. Chem. 279, 54716-54723
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Transient Cerebral Ischemia Induces Aberrant Neuronal Cell Cycle Re-entry and Alzheimer's Disease-like Tauopathy in Female Rats.
Y. Wen, S. Yang, R. Liu, A. M. Brun-Zinkernagel, P. Koulen, and J. W. Simpkins (2004)
J. Biol. Chem. 279, 22684-22692
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Regulators of Cerebellar Granule Cell Development Act Through Specific Signaling Pathways.
D. Vaudry, A. Falluel-Morel, S. Leuillet, H. Vaudry, and B. J. Gonzalez (2003)
Science 300, 1532-1534
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Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761.
Y. Luo, J. V. Smith, V. Paramasivam, A. Burdick, K. J. Curry, J. P. Buford, I. Khan, W. J. Netzer, H. Xu, and P. Butko (2002)
PNAS 99, 12197-12202
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Science. ISSN 0036-8075 (print), 1095-9203 (online)