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Science 14 September 2001:
Vol. 293. no. 5537, pp. 2010 - 2011
DOI: 10.1126/science.1064980
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Perspectives

TRANSCRIPTION:
Transcription Factor IID--Not So Basal After All

C. Peter Verrijzer

How does a fertilized egg give rise to the more than 200 types of differentiated cells in our bodies? As Verrijzer explains in his Perspective, different components of the general transcription factor TFIID, such as the TAFIIs, ensure that crucial developmental genes are switched on in a tissue-specific manner. Thus, TFIID, which has always been considered a general transcription factor, can be tailored by TAFIIs to the specialist needs of developing tissues.

The author is in the Department of Molecular and Cell Biology, MGC, Centre for Biomedical Genetics, Leiden University Medical Centre, Leiden, Netherlands. E-mail: verrijzer{at}lumc.nl

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