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Women pregnant for the first time are particularly susceptible to malaria. This finding has been attributed to the ability of some malaria-infected red cells to bind to and become sequestered within the placenta. In a Perspective, Duffy and Fried describe new findings (Flick et al.) showing that malaria-infected red cells are coated in nonimmune immunoglobin G that enables them to bind to the Fc receptors expressed by the placental lining.
The authors are at the Seattle Biomedical Research Institute, Seattle, WA 98109, USA, and Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA. E-mail: pduffy{at}sbri.org
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In Science Magazine
REPORTS
Kirsten Flick, Carin Scholander, Qijun Chen, Victor Fernandez, Bruno Pouvelle, Jurg Gysin, and Mats Wahlgren (14 September 2001) Science293 (5537), 2098.
[DOI: 10.1126/science.1062891] |Abstract »|Full Text »|PDF »
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