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Science 7 September 2001:
Vol. 293. no. 5536, pp. 1784 - 1785
DOI: 10.1126/science.11546862
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Perspectives

APOPTOSIS:
Till Death Us Do Part

Abigail Hunt and Gerard Evan

Epithelial cells need to remain firmly attached to each other and to the extracellular matrix. In the event that these cells become detached, they undergo apoptosis. In a Perspective, Hunt and Evan discuss new work that identifies the trigger that sets in motion the apoptosis program following detachment (Puthalakath et al.). The trigger turns out to be the pro-apoptotic protein Bmf. This protein is attached to the myosin V motor complex of the actin cytoskeleton under normal conditions, but is set free once cells become detached.

The authors are at the University of California-San Francisco Cancer Center, San Francisco, CA 94143, USA.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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S. D. Smith, C. E. Dunk, J. D. Aplin, L. K. Harris, and R. L. Jones (2009)
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Synthesis of the Blood Circulating C-terminal Fragment of Insulin-like Growth Factor (IGF)-binding Protein-4 in Its Native Conformation: CRYSTALLIZATION, HEPARIN AND IGF BINDING, AND OSTEOGENIC ACTIVITY.
C. Fernandez-Tornero, R. M. Lozano, G. Rivas, M. A. Jimenez, L. Standker, D. Diaz-Gonzalez, W.-G. Forssmann, P. Cuevas, A. Romero, and G. Gimenez-Gallego (2005)
J. Biol. Chem. 280, 18899-18907
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Minimal BH3 Peptides Promote Cell Death by Antagonizing Anti-apoptotic Proteins.
C. Moreau, P.-F. Cartron, A. Hunt, K. Meflah, D. R. Green, G. Evan, F. M. Vallette, and P. Juin (2003)
J. Biol. Chem. 278, 19426-19435
   Abstract »    Full Text »    PDF »
c-Myc Functionally Cooperates with Bax To Induce Apoptosis.
P. Juin, A. Hunt, T. Littlewood, B. Griffiths, L. B. Swigart, S. Korsmeyer, and G. Evan (2002)
Mol. Cell. Biol. 22, 6158-6169
   Abstract »    Full Text »    PDF »
Critical Requirement of BAX for Manifestation of Apoptosis Induced by Multiple Stimuli in Human Epithelial Cancer Cells.
P. Theodorakis, E. Lomonosova, and G. Chinnadurai (2002)
Cancer Res. 62, 3373-3376
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Science. ISSN 0036-8075 (print), 1095-9203 (online)