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Science 17 August 2001:
Vol. 293. no. 5533, pp. 1263 - 1264
DOI: 10.1126/science.1064602
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Perspectives

CELL BIOLOGY:
A Switch to Release the Motor

Richard E. Cheney and Olga C. Rodriguez

Most organelle transport ceases when cells begin mitosis. But how is this accomplished? As Cheney and Rodriguez explain in their Perspective, cell cycle-dependent phosphorylation of myosin-V--a motor protein that moves organelles along actin filaments--results in release of myosin-V from the organelle and cessation of actin-based organelle transport (Karcher et al.).

The authors are in the Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. E-mail: cheneyr{at}med.unc.edu

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