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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1064 - 1067
DOI: 10.1126/science.293.5532.1064
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Behind the Scenes of Gene Expression

Elizabeth Pennisi

As the units of DNA that define the proteins needed for life, genes have played biology's center stage for decades. But work over the past few years shows that gene expression is not determined solely by the DNA code itself but by an assortment of proteins and, sometimes, RNAs that tell the genes when and where to turn on or off. Such epigenetic phenomena orchestrate the many changes through which a single fertilized egg cell turns into a complex organism. And throughout life, they enable cells to respond to environmental signals conveyed by hormones, growth factors, and other regulatory molecules without having to alter the DNA itself.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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P. M. Strozycki, A. Szczurek, B. Lotocka, M. Figlerowicz, and A. B. Legocki (2007)
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The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy.
S. P. Whitman, S. Liu, T. Vukosavljevic, L. J. Rush, L. Yu, C. Liu, M. I. Klisovic, K. Maharry, M. Guimond, M. P. Strout, et al. (2005)
Blood 106, 345-352
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Global methylation screening in the Arabidopsis thaliana and Mus musculus genome: applications of virtual image restriction landmark genomic scanning (Vi-RLGS).
T. Matsuyama, M. T. Kimura, K. Koike, T. Abe, T. Nakano, T. Asami, T. Ebisuzaki, W. A. Held, S. Yoshida, and H. Nagase (2003)
Nucleic Acids Res. 31, 4490-4496
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Epigenetics and DNA Methylation Come of Age in Toxicology.
R. E. Watson and J. I. Goodman (2002)
Toxicol. Sci. 67, 11-16
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