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Science 10 August 2001:
Vol. 293. no. 5532, pp. 1058 - 1059
DOI: 10.1126/science.1063290
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Perspectives

PROTEIN SYNTHESIS:
Believe It or Not--Translation in the Nucleus

Matthias W. Hentze

Protein synthesis dogma holds that mRNAs are transcribed and processed in the nucleus and are then exported to the cytoplasm where they are translated by ribosomes into protein. As Hentze explains in his Perspective, this dogma is now facing a formidable challenge: clever experiments that provide strong support in favor of mRNA translation and protein synthesis taking place in the nucleus (Iborra et al.).

The author is in the Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany. E-mail: hentze{at}embl-heidelberg.de

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