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Also see the archival list of the Essays on Science and Society.
ESSAYS ON SCIENCE AND SOCIETY: Defining Disease in the Genomics Era
Larissa K. F. Temple, Robin S. McLeod, Steven Gallinger, James G. Wright
With sequencing of the human genome complete and comparative analyses of genetic variations among individuals well under way, there is increasing uncertainty about which variations are associated with disease. In a Science and Society Essay, Temple and colleagues discuss the need for an explicit definition of disease that takes into consideration possible risks and adverse consequences associated with genetic variations, while at the same time acknowledging that a disease cannot be defined by a single genetic variation.
L. K. F. Temple, R. S. McLeod, and S. Gallinger are in the Department of Surgery, University of Toronto, Mount Sinai Hospital, Samuel Lunenfeld Research Institute, Toronto, ON, Canada M5G 1X5. J. G. Wright is in the Departments of Surgery, Public Health Sciences, and Health Policy, Management and Evaluation, University of Toronto, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. E-mail: jim.wright{at}sickkids.ca
Incomplete overlapping of biological, clinical, and environmental information in molecular epidemiological studies: a variety of causes and a cascade of consequences.
M Porta, N Malats, J Vioque, A Carrato, M Soler, L Ruiz, V Barbera, D Ayude, and F X Real (2002)
J. Epidemiol. Community Health
56, 734-738
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