Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
IMMUNOLOGY: The Push-Me Pull-You of T Cell Activation
Monica J. Carson and David Lo
What causes the aberrant immune responses that result in chronic multiorgan autoimmune diseases such as systemic lupus erythematosus (SLE)? As Carson and Lo explain in their Perspective, new findings suggest that the lysophospholipid LPC--generated during the breakdown of low density lipoproteins and plasma membranes--is a master inhibitor of T cell activation (Kabarowski et al.). Defects in the LPC pathway could lower the threshold for T cell activation leading to SLE and other multiorgan autoimmune diseases.
M. J. Carson is in the Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. D. Lo is at Digital Gene Technologies Inc., 11149 North Torrey Pines Road, La Jolla, CA 92037, USA. E-mail: carson{at}scripps.edu, davidlo{at}dgt.com
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Janusz H. S. Kabarowski, Kui Zhu, Lu Q. Le, Owen N. Witte, and Yan Xu (27 July 2001) Science293 (5530), 702.
[DOI: 10.1126/science.1061781] |Abstract »|Full Text »|PDF »|Supplemental Data »
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adenovirus-mediated gene transfer of Lp-PLA2 reduces LDL degradation and foam cell formation in vitro.
P. Turunen, J. Jalkanen, T. Heikura, H. Puhakka, J. Karppi, K. Nyyssonen, and S. Yla-Herttuala (2004)
J. Lipid Res.
45, 1633-1639
|Abstract »|Full Text »|PDF »
Sphingosylphosphorylcholine and Lysophosphatidylcholine Are Ligands for the G Protein-coupled Receptor GPR4.
K. Zhu, L. M. Baudhuin, G. Hong, F. S. Williams, K. L. Cristina, J. H. S. Kabarowski, O. N. Witte, and Y. Xu (2001)
J. Biol. Chem.
276, 41325-41335
|Abstract »|Full Text »|PDF »
