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MICROBIOLOGY: S. pneumoniae Genome Falls to Sequencers
Dan Ferber
Researchers have uncovered clues to just what makes Streptococcus pneumoniae, which kills millions every year, so savage. On page 498, researchers report the exact order of the 2.16 million bases that make up the genetic code of a virulent S. pneumoniae strain. By examining the sequence and comparing it with those of other strains, the team found that the microbe is particularly well equipped to invade the body's tissues. It also seems very adept at shuffling its genes-an ability that may help it evade the immune system.
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REPORTS
Hervé Tettelin, Karen E. Nelson, Ian T. Paulsen, Jonathan A. Eisen, Timothy D. Read, Scott Peterson, John Heidelberg, Robert T. DeBoy, Daniel H. Haft, Robert J. Dodson, A. Scott Durkin, Michelle Gwinn, James F. Kolonay, William C. Nelson, Jeremy D. Peterson, Lowell A. Umayam, Owen White, Steven L. Salzberg, Matthew R. Lewis, Diana Radune, Erik Holtzapple, Hoda Khouri, Alex M. Wolf, Terry R. Utterback, Cheryl L. Hansen, Lisa A. McDonald, Tamara V. Feldblyum, Samuel Angiuoli, Tanja Dickinson, Erin K. Hickey, Ingeborg E. Holt, Brendan J. Loftus, Fan Yang, Hamilton O. Smith, J. Craig Venter, Brian A. Dougherty, Donald A. Morrison, Susan K. Hollingshead, and Claire M. Fraser (20 July 2001) Science293 (5529), 498.
[DOI: 10.1126/science.1061217] |Abstract »|Full Text »|PDF »|Supplemental Data »
