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Science 13 July 2001:
Vol. 293. no. 5528, pp. 227 - 228
DOI: 10.1126/science.1062892
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Perspectives

Also see the archival list of Science's Compass: Enhanced Perspectives

CANCER:
Enhanced: What Does Radiotherapy Do to Endothelial Cells?

Judah Folkman and Kevin Camphausen

It has been presumed that the severe gastrointestinal side effects accompanying radiotherapy in cancer patients result from the radiation-induced death of epithelial stem cells in the intestinal crypts. As Folkman and Camphausen explain in their Perspective, this view may change with the findings of Paris et al., who show that the principal gut cells dying in response to radiation are the endothelial cells of the gut microvasculature. Gut epithelial stem cells die because they depend on microvascular endothelial cells for survival, a situation reminiscent of the dependence of tumor cells on endothelial cell proliferation and the growth of new blood vessels.

J. Folkman is in the Department of Surgery, Children's Hospital, and K. Camphausen is in the Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115, USA.

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